The pathogenesis of B cell malignancies is a dynamic process The pathogenesis of B cell malignancies is a dynamic process involving reciprocal interactions between malignant cells and surrounding components in...
Featuring World-Renowned Flow Cytometry Expert: Dr. John Connolly Wednesday, October 21, 2020 1 p.m. SGT [caption id="attachment_6580" align="alignnone" width="314"] Dr. John Connolly[/caption] A complex interaction of anabolic and catabolic metabolism A...
Haematopoiesis and tumour growth During haematopoiesis, multilineage blood cells are generated successively from a series of lineage-restricted progenitor cells, in turn, derived from haematopoietic stem cells. Haematopoietic stem and progenitor cells (HSPCs) are usually localised in the bone...
A key step in the clinical production of CAR T cells is the expansion of engineered T cells. To generate enough cells for viable adoptive cell therapy, cells must be robustly stimulated, which raises the risk of inducing T-cell exhaustion and reducing therapeutic efficacy. We sought to answer fundamental questions about the impact of in […]
Learning panel design Panel design is one of the most crucial parts of a flow-cytometry experiment. It involves the selection of the right combination of marker and fluorochrome for a given population of cells under study. A badly designed panel, comprising of improperly selected fluorochromes results in overlapping of emission spectra, leading to loss of […]
SKP2 mediated BECN1 ubiquitination, its role in autophagy, and how its inhibition reduces MERS-Coronavirus replication Autophagy is an important mechanism used by host cells to counter viral infections. In this process, double-membrane vesicles called autophagosomes deliver viral cargo to the lysosomes for degradation. Autophagy also coordinates the presentation of the virus-derived antigens to T […]
In recent times, developments in genomics, proteomics and single-cell technologies, coupled with advances in allied areas like computing and antibody engineering have enabled significant progress in drug development. Current drug development platforms, however, take only simplified cellular models or molecular readouts into account at the functional level. This makes it difficult to evaluate the effects […]
Targets of T cell responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals The rapid spread of COVID-19 infections all over the world and the need to develop a vaccine has necessitated the understanding of the adaptive immune response to the SARS-CoV-2 virus. There is an urgent requirement to evaluate the response […]
You have often wished to have a desktop ready reference for all the BD fluorochromes – a small, convenient tool like a ready reckoner. That is why we have brought you the BDB reagent fluorocards. These are a set of plastic cards with information about the entire family of BD fluorochromes, one per card. The […]
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been rapidly spreading, leading to considerable morbidity and mortality worldwide. High infectivity of the virus, asymptomatic transmission and lack of effective anti-viral drugs and vaccines have made management of COVID-19 challenging. The continuous efforts to understand the immune response to SARS-CoV-2 infection […]
The high-dimensional flow cytometry portfolio by BD has been silently working in labs all around the world, performing cutting-edge multi-colour experiments at the very frontiers of immunology. Many high-impact publications and optimised multi-colour immunofluorescence panels (OMIPs) have resulted, revealing fascinating insights into a variety of research questions. To give a taste of what high-dimensional flow […]
You have always wished to expand the realms of your research into the unknown. Now BD is about to help you do just that. Our portfolio comprising of multicolour flow cytometry, cDNA library preparation, single-cell RNA sequencing and advanced data analysis tools will give you unprecedented insights into the working of single-cells. What is more, […]
BD Biosciences is proud to present a series of educational videos, aptly titled ‘Scientist to Scientist Educational Series’, featuring insightful advice by BD scientists on how to get better and more impactful flow cytometry data by designing the correct panel. Click HERE to watch the videos and stay tuned for more videos in the coming months.