Chronic Lymphoid Leukemia (CLL), the most common form of leukemia in adults, is often characterised by progressive accumulation of incompetent lymphocytes in blood and bone marrow. Recent bulk RNA studies...
Simultaneous single-cell mRNA and epitope mapping of human CD4+ T-cells using the BD Rhapsody™ and the BD™ AbSeq platform “ Currently a senior post-doctoral fellow in John Todd’s lab at the University of Oxford, my primary research aims...
Enable discoveries and get to your next breakthrough moment faster! The BD FACSMelody™ offers high-end sorting in an easy-to-use package for any researcher. It has been contributing to the research in cutting-edge areas like stem cell research, multiomics, immunology and cancer research. Here, we present a list of publications in high-impact journals, citing the BD FACSMelody™. […]
“The FACSMelody™ is very simple to use. We can train a user within an hour, even if they have limited flow cytometry experience”, says Dr. Andrea L. Holme, Senior Lecturer for Cytometry at the University of Western Australia, and a happy BD FACSMelody™ user. Watch the video to learn about the work being done by […]
The various species of bacteria inhabiting human and animal bodies, particularly in the gut microbiota, play key roles in many biological processes. Important health issues like undernutrition, irritable bowel syndrome, metabolic disorders, skin diseases and many others are linked to gut bacteria and their functions. As bacteria in the gut are anaerobic and cannot be […]
The human immune system fights not only external pathogens but also clears internal abnormalities like dying and cancer cells. The cancer immunity cycle begins when antigens produced by tumor cells are processed by dendritic cells for antigen presentation. This is followed by additional signals that activate and induce anti-tumor response by T cells, eventually resulting […]
B-cell diversity is generated by a highly regulated, multistep process. Abnormal B-cell development and function can lead to malignant transformation. Advances in the understanding of the regulatory process that control B-cell lymphopoiesis and function have enabled proper classification of B-cell neoplasms and the development of targeted therapies. The attached poster enables you to get an […]
BD Biosciences organized the first BD ever single-cell multi-omics user group meeting at BD headquarters, Winnersh in March 2019, in the UK. The aim of this event was to bring together users of the BD multi-omics technology and share their work & experience. An exciting day resulted with the speakers talking about how the BD […]
By Dr. Wendy Beguelin, Weil Cornell Medical College. A multiomics approach During humoral immune response or infections, subsets of B-cells migrate to germinal centres in lymphoid follicles located in the lymph nodes and the spleen. Some of these germinal centre B-cells (GC B-cells) differentiate into memory B-cells and plasma cells. Understanding the biology of GC […]
Evaluating the expression patterns of multiple inhibitory receptors Persistent antigen stimulation of T-cells, typically observed during chronic infections or in tumor microenvironments, results in the loss of antigen-specific CD8+ T-cell effector function. This phenomenon is referred to as T-cell exhaustion and is characterised by the progressive loss of function and proliferative capacity, eventually resulting in […]
The past two years have seen the “cell therapy revolution” begin It now sees the patient’s cells being modified to fight a disease. This revolution brings along unique challenges from discovery through clinical trials to the clinic. An evolving regulatory landscape, rapid advances in manufacturing technologies, products with complex mechanism of action and inherent variability […]