Abstract: The composition of the immune infiltrate in the human tumor microenvironment is a critical determinant of disease progression. Immunotherapies to treat cancer have achieved remarkable successes, but an inherent...
Flow cytometry is serious science, but shouldn’t science be fun? Any scientist will tell you that the adventure of discovery and the thrill of experimentation make for a very exciting experience. We at BD Biosciences have always supported...
The BD FACSymphony™ family of cell analysers has enabled the simultaneous detection of 30-50 parameters, thereby helping labs leverage and enhance the power of flow cytometry. BD FACSymphony™ analysers are highly customisable to meet your research priorities and can be configured to satisfy your needs, both present and future. This family of analysers has been […]
Yu YR, Imrichova H, Wang H, et al. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. The anti-tumor activity of Tumor-Infiltrating T Lymphocytes (TILs) can be attenuated by metabolic challenges present in tumors. The tumour microenvironment (TME) is home to many factors that impose restrictions on the anti-tumor […]
At BD Biosciences, our customers are the most important part of our work. Providing the vital bridge between BDB and the customers is our team of dedicated and talented Application Specialists. This group of efficient and proactive people is available for the customers all the time, attending to their calls and solving their problems. So […]
Organoids are three-dimensional assemblies of cultured cells that reiterate important aspects of organ development and provide an insight into biological function. They are viable, in vitro models of human physiology and can be used for interventional studies that are not possible in human subjects. Organoids reflect human biology and allow for genetic manipulation and complex […]
Why identifying antigen-specific epitopes and their cognate T-cell receptors is important In immunology, identifying antigen-specific epitopes and their cognate T-cell receptors can yield useful insights into the functioning of T-cells and can provide vital information for vaccine development. dCODE Dextramer® (RiO) reagents are DNA barcoded MHC Dextramer® products compatible with the BD RhapsodyTM Single-Cell Analysis System. Each […]
It has always been difficult to find the impossible, but what makes it so? To unravel the secrets of single-cells it is important to start the experiment with viable and live cells. The BD Multi-Omics workflow enables this using visual metrics, providing you with accurate information about cell counts and viability along the entire process. […]
Introduction Dendritic cells (DC) and monocytes, along with macrophages, constitute the Mononuclear Phagocyte System (MPS), which scans for and provides the first line of defence against invading pathogens. Some cells of the MPS internalise the invading pathogens. These cells are called Professional Antigen Presenting Cells (APC). Following the internalisation, these cells also play a key […]
Importance of CD4 and CD8 T cells CD4 and CD8 T cells are important in viral killing and antibody response. T-cell subsets typically decrease with increasing disease severity in COVID-19 patients.1 Upon admission in hospitals, a major challenge for clinicians is to determine whether a COVID-19 patient faces an increased risk of intubation with mechanical […]
BD Biosciences is proud to present a series of educational videos, aptly titled ‘Scientist to Scientist Educational Series’, featuring insightful advice by BD scientists on how to get better and more impactful flow cytometry data by designing the correct panel. Click HERE to watch the videos and stay tuned for more videos in the coming months.