Webinar: Single-cell transcriptomics of PBMCs from COVID-19 patients using the BD Rhapsody™ platform

News & Event

The COVID-19 pandemic is an ongoing global challenge. It is a mild to moderate respiratory tract infection in most people but can cause life-threatening respiratory failure or persistent debilitating symptoms in a subset of patients.1 The mechanisms of protective immunity in mild cases and the pathogenesis of severe COVID-19 remain unclear. It has been proposed […]

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Multi-omics characterization of T-cell populations at the single-cell level utilizing sensitive dCODE Dextramer® and the BD® AbSeq on the BD Rhapsody™ Single-Cell Analysis System

News & innovations, The Cytohub

Why identifying antigen-specific epitopes and their cognate T-cell receptors is important In immunology, identifying antigen-specific epitopes and their cognate T-cell receptors can yield useful insights into the functioning of T-cells and can provide vital information for vaccine development. dCODE Dextramer® (RiO) reagents are DNA barcoded MHC Dextramer® products compatible with the BD RhapsodyTM Single-Cell Analysis System. Each […]

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Visual metrics in BD Multi-Omics: Your key to finding the impossible!

The Cytohub

It has always been difficult to find the impossible, but what makes it so? To unravel the secrets of single-cells it is important to start the experiment with viable and live cells. The BD Multi-Omics workflow enables this using visual metrics, providing you with accurate information about cell counts and viability along the entire process. […]

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CRISPR screens using targeted single-cell RNA sequencing

Scientific Publication

Cell perturbation using the CRISPR technique Earlier on www.flowcytometry-news.com, we featured an article on the use of the BD Rhapsody™ system to perform highly scalable and more sensitive CRISPR screens. In cell perturbation using the CRISPR technique, single guide RNAs (sgRNAs) are used to guide the endonuclease Cas9 to create a targeted double-strand break, the […]

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Leveraging the power of high-parameter cell sorting and single-cell multi-omics to profile intra-tumoral immune cells in a model of B cell lymphoma

Scientific Publication

The pathogenesis of B cell malignancies is a dynamic process The pathogenesis of B cell malignancies is a dynamic process involving reciprocal interactions between malignant cells and surrounding components in the tumour microenvironment. In the case of certain B cell lymphomas, neoplastic cells migrate to lymphoid sites and prompt the infiltration of non-malignant immune cells. […]

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