BD Rhapsody
Bifidobacteria-mediated immune system imprinting early in life
Scientific PublicationHenrick et al., Bifidobacteria-mediated immune system imprinting early in life, Cell (2021), https://doi.org/ 10.1016/j.cell.2021.05.030 There is mounting evidence to suggest that during the first 3 months of life, the infant gut microbiome is crucial for immune development. Specialised microbes in the infant gut that rely on breast milk for nutrients play a key role in […]
Continue reading
Webinar: Single-cell transcriptomics of PBMCs from COVID-19 patients using the BD Rhapsody™ platform
News & EventThe COVID-19 pandemic is an ongoing global challenge. It is a mild to moderate respiratory tract infection in most people but can cause life-threatening respiratory failure or persistent debilitating symptoms in a subset of patients.1 The mechanisms of protective immunity in mild cases and the pathogenesis of severe COVID-19 remain unclear. It has been proposed […]
Continue reading
Multi-omics characterization of T-cell populations at the single-cell level utilizing sensitive dCODE Dextramer® and the BD® AbSeq on the BD Rhapsody™ Single-Cell Analysis System
News & innovations, The CytohubWhy identifying antigen-specific epitopes and their cognate T-cell receptors is important In immunology, identifying antigen-specific epitopes and their cognate T-cell receptors can yield useful insights into the functioning of T-cells and can provide vital information for vaccine development. dCODE Dextramer® (RiO) reagents are DNA barcoded MHC Dextramer® products compatible with the BD RhapsodyTM Single-Cell Analysis System. Each […]
Continue reading
Visual metrics in BD Multi-Omics: Your key to finding the impossible!
The CytohubIt has always been difficult to find the impossible, but what makes it so? To unravel the secrets of single-cells it is important to start the experiment with viable and live cells. The BD Multi-Omics workflow enables this using visual metrics, providing you with accurate information about cell counts and viability along the entire process. […]
Continue reading
CRISPR screens using targeted single-cell RNA sequencing
Scientific PublicationCell perturbation using the CRISPR technique Earlier on www.flowcytometry-news.com, we featured an article on the use of the BD Rhapsody™ system to perform highly scalable and more sensitive CRISPR screens. In cell perturbation using the CRISPR technique, single guide RNAs (sgRNAs) are used to guide the endonuclease Cas9 to create a targeted double-strand break, the […]
Continue reading
Leveraging the power of high-parameter cell sorting and single-cell multi-omics to profile intra-tumoral immune cells in a model of B cell lymphoma
Scientific PublicationThe pathogenesis of B cell malignancies is a dynamic process The pathogenesis of B cell malignancies is a dynamic process involving reciprocal interactions between malignant cells and surrounding components in the tumour microenvironment. In the case of certain B cell lymphomas, neoplastic cells migrate to lymphoid sites and prompt the infiltration of non-malignant immune cells. […]
Continue reading
