Mitochondria

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

Yu YR, Imrichova H, Wang H, et al. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. The anti-tumor activity of Tumor-Infiltrating T Lymphocytes (TILs) can be attenuated by metabolic challenges present in tumors. The tumour microenvironment (TME) is home to many factors that impose restrictions on the anti-tumor […]