Webinar: Single-cell profiling of human tumors and inflamed tissues reveals therapeutically targetable tumor-unique immune subsets

News & Event

Abstract: The composition of the immune infiltrate in the human tumor microenvironment is a critical determinant of disease progression. Immunotherapies to treat cancer have achieved remarkable successes, but an inherent weakness of current treatment approaches is that the targeted immune subsets are not exclusive to tumors. In an effort to identify tumor-unique immune features that […]

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Labventure – Fun and games in flow cytometry

News & Event

Flow cytometry is serious science, but shouldn’t science be fun? Any scientist will tell you that the adventure of discovery and the thrill of experimentation make for a very exciting experience. We at BD Biosciences have always supported the playful side of science. So, we came up with a game that lets you choose your […]

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The organoid cell atlas

Scientific Publication

Organoids are three-dimensional assemblies of cultured cells that reiterate important aspects of organ development and provide an insight into biological function. They are viable, in vitro models of human physiology and can be used for interventional studies that are not possible in human subjects. Organoids reflect human biology and allow for genetic manipulation and complex […]

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Multi-omics characterization of T-cell populations at the single-cell level utilizing sensitive dCODE Dextramer® and the BD® AbSeq on the BD Rhapsody™ Single-Cell Analysis System

News & innovations, The Cytohub

Why identifying antigen-specific epitopes and their cognate T-cell receptors is important In immunology, identifying antigen-specific epitopes and their cognate T-cell receptors can yield useful insights into the functioning of T-cells and can provide vital information for vaccine development. dCODE Dextramer® (RiO) reagents are DNA barcoded MHC Dextramer® products compatible with the BD RhapsodyTM Single-Cell Analysis System. Each […]

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CRISPR screens using targeted single-cell RNA sequencing

Scientific Publication

Cell perturbation using the CRISPR technique Earlier on www.flowcytometry-news.com, we featured an article on the use of the BD Rhapsody™ system to perform highly scalable and more sensitive CRISPR screens. In cell perturbation using the CRISPR technique, single guide RNAs (sgRNAs) are used to guide the endonuclease Cas9 to create a targeted double-strand break, the […]

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Webinar: Single-cell multi-omics identifies unstable regulatory T-cell profiles

The Cytohub

Webinar by Prof. Susan Schlenner, University of Leuven, Belgium Regulatory T cells (Tregs) are a subset of CD4+ T cells that possess immunosuppressive functions.  They play a key role in human health as their malfunction results in allergies and auto-inflammatory disorders. Loss of regulatory T cells results in a rare autoimmune polyendocrine syndrome called IPEX, […]

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Leveraging the power of high-parameter cell sorting and single-cell multi-omics to profile intra-tumoral immune cells in a model of B cell lymphoma

Scientific Publication

The pathogenesis of B cell malignancies is a dynamic process The pathogenesis of B cell malignancies is a dynamic process involving reciprocal interactions between malignant cells and surrounding components in the tumour microenvironment. In the case of certain B cell lymphomas, neoplastic cells migrate to lymphoid sites and prompt the infiltration of non-malignant immune cells. […]

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