The role of immune checkpoint receptors in cancer immunity

The human immune system fights not only external pathogens but also clears internal abnormalities like dying and cancer cells. The cancer immunity cycle begins when antigens produced by tumor cells are processed by dendritic cells for antigen presentation. This is followed by additional signals that activate and induce anti-tumor response by T cells, eventually resulting in the killing of tumor cells.

To prevent over-stimulation in the presence of  antigens associated with tumor cells, the immune system has several receptors that negatively regulate its functions. Referred to as checkpoint receptors, these control the initiation of a productive immune response and prevent excessive T cell activation that could lead to inflammatory autoimmune processes. However, tumor cells often utilize immune checkpoints to favour growth. The blocking of checkpoint receptors like CTLA-4 or PD-1 allows the immune system to overcome their regulatory mechanisms and provide a robust anti-tumor response. Conversely, the activation of checkpoint receptors in autoimmune diseases helps in reducing inflammation.

To learn more about checkpoint receptors and their interactions, download the poster <here>.

 

BD and the BD Logo are trademarks of Becton, Dickinson and Company © 2019 BD and its subsidiaries. All rights reserved.
For research use only. Not for use in diagnostic or therapeutic procedures.

Newsletter

Do not miss any essential information join us :)

Send me the Flowcytometry News newsletter. I expressly agree to receive the newsletter and know that I can easily unsubscribe at any time.

Diary

Stay up to date on what happens in Flowcytometry News !

Register and receive our newsletter each month

Send me the Flowcytometry News newsletter. I expressly agree to receive the newsletter and know that I can easily unsubscribe at any time.