Origin of normal and neoplastic B-cells

B-cell diversity is generated by a highly regulated, multistep process. Abnormal B-cell development and function can lead to malignant transformation. Advances in the understanding of the regulatory process that control B-cell lymphopoiesis and function have enabled proper classification of B-cell neoplasms and the development of targeted therapies. The attached poster enables you to get an in-depth understanding of B-cell lymphopoiesis, activation and differentiation. It also helps you understand B-cell malignancies based on a cell-of-origin approach, and the signaling and transcription networks that can be targeted for therapy.

Download the poster here <link to poster>

 

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