The expression of CCR7 (CD197), a chemokine receptor that controls homing to secondary lymphoid organs, allows the differentiation of human memory T cells into functionally different subsets.1 CCR7+ memory cells express lymph-node homing receptors, efficiently stimulate dendritic cells and differentiate into CCR7- effector cells upon secondary stimulation. CCR7- memory cells express receptors for migration to inflamed tissues and display immediate effector function.
A new monoclonal antibody offered by BD (clone 2-L1-A) provides superior staining characteristics and better separation of CCR7 than the existing one (clone 150503). Download the brochure here to learn more.
1 F. Sallusto et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708–712 (1999)