Overview of Dendritic Cell Development

Dendritic cells (DCs), a vital part of the innate and adaptive immune system, are antigen-sensing and presenting cells uniquely possessing the ability to induce primary immune response.1 Due to their important role in the immune system, there is great interest in studying DCs to develop therapies for cancer, chronic infections, autoimmune diseases and for transplantation tolerance. 2-4

During DC development, immature DCs from the progenitor cells in the bone marrow migrate to practically all the lymphoid and non-lymphoid tissues in the body. A diverse array of transcription factors, signaling molecules, growth factors, chemokines, cytokines and adhesion receptors have been implicated in the differentiation pathway of immature to mature DCs. In addition, further maturation of DCs is brought about by surface pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and C-type lectin receptors (CLRs). 5,6

This poster gives an overview of the core DC phenotyping and subset markers in humans and mice. Click <here> to download the poster.

  1. O’Keeffe M, Mok WH, Radford KJ. Human dendritic cell subsets and function in health and disease.  Cell Mol Life Sci.2015;72:4309-4325.
  2. Apostolopoulos V, Thalhammer T, Tzakos AG, Stojanovska L. Targeting antigens to dendritic cell receptors for vaccine development.  J Drug Deliv.2013;2013:869718.
  3. Cohn L, Delamarre L. Dendritic cell-targeted vaccines.  Front Immunol.2014;5:255.
  4. Delamarre L, Mellman I. Harnessing dendritic cells for immunotherapy.  Sem Immunol.2011;23:2-11.
  5. Swiecki M, Colonna M. The multifaceted biology of plasmacytoid dendritic cells.  Nat Rev Immunol.2015;15:471-485.
  6. Murphy TL, Grajales-Reyes GE, Wu X, et al. Transcriptional control of dendritic cell development.  Annu Rev Immunol.2016;34:93-119.
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